For many years, there has been no model capable of explaining the complex processes of interaction between various bloodclotting factors leading to a stop of bleeding.One of the most successful models able to partially reflect the mechanisms of hemostasis for a long time was the cascade theory.The cascade model perfectly explains the processes occu
Functional resistance activities to impact frailty: A protocol for a randomized controlled trial involving home care aide and frail older adult dyads
Background: A growing number of older adults use in-home Medicaid Waiver Home and Community Based services (HCBS) to facilitate aging-in-place.A primary service of this program is Home Care Aide assistance with activities of daily living and homemaker needs.Despite the known benefits of exercise, exercise programs are currently not offered Terminal
Sexual dimorphism and geographical male polymorphism in the ghost moth Hepialus humuli (Lepidoptera: Hepialidae): Scale ultrastructure and evolutionary aspects
Throughout most of its range the Palaearctic moth Hepialus humuli shows a striking sexual dimorphism correlated with a dimorphism in wing scale ultrastructure.Male uppersides are uniformly silvery white, due to light reflection from unpigmented scales with an elaborate internal cuticular meshwork; the conspicuous wings are visual cues for females w
Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis
How phosphate levels are detected in mammals is unknown.The bone-derived hormone fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney phosphate reabsorption and 1,25(OH)2D production, but phosphate does not directly stimulate bone FGF23 expression.Using PET scanning and LC-MS, we found that phosphate increases kidney